Such findings underpin the application of drugs which activate the nmda receptors as possible novel antipsychotics thus glycine and d serine as nmda receptor agonists have been studied for their potential antipsychotic effects high doses of glycine 30 60 g day have been shown to improve the negative symptoms in schizophrenia. The results of clinical trials of the newer antipsychotic drugs such as clozapine risperidone olanzapine amisulpride quetiapine and sertindole suggest a lower liability for acute extrapyramidal symptoms than conventional antipsychotic drugs such as haloperidol and chlorpromazine. The typicality of atypical antipsychotic drugs remains debatable preclinical studies and findings from randomized controlled and open trials of clozapine olanzapine risperidone quetiapine sertindole ziprasidone and a substituted benzamide were examined
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